A ginsenoside with diverse biological activities; prevents tubular cell apoptosis

Pseudoginsenoside F11 – 25 mg

Brand:
Cayman
CAS:
69884-00-0
Storage:
-20
UN-No:
Non-Hazardous - /

Pseudoginsenoside F11 is an ocotillol-type ginsenoside that has been found in P. ginseng and has diverse biological activities.{54075,54076,54077,54078} In vivo, pseudoginsenoside F11 (10 mg/kg) prevents tubular cell apoptosis, decreases in renal glutathione peroxidase (GPX) and superoxide dismutase (SOD) levels, and increases in renal lipid peroxide levels in a rat model of nephrotoxicity induced by cisplatin (Item No. 13119).{54075} It reduces infarct size, brain water content, and cortical accumulation of autophagosomes in a rat model of ischemic stroke induced by permanent middle cerebral artery occlusion.{54076} Pseudoginsenoside F11 (4 and 8 mg/kg) inhibits morphine-induced memory impairment in the Morris water maze and development of morphine-induced conditioned place preference in mice.{54077} It also reduces hippocampal advanced glycation end product (AGE) and malondialdehyde (MDA) levels, increases hippocampal SOD activity and glutathione (GSH) levels, and attenuates cognitive impairment in the Morris water maze in a mouse model of D-galactose-induced mild cognitive impairment.{54078}  

 

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SKU: 30222 - 25 mg Category:

Description

A ginsenoside with diverse biological activities; prevents tubular cell apoptosis, decreases in renal GPX and SOD levels, and increases in renal lipid peroxide levels in a rat model of cisplatin-induced nephrotoxicity at 10 mg/kg; reduces infarct size, brain water content, and cortical accumulation of autophagosomes in a rat model of ischemic stroke induced by permanent middle cerebral artery occlusion; inhibits morphine-induced memory impairment in the Morris water maze and development of morphine-induced conditioned place preference in mice at 4 and 8 mg/kg; reduces hippocampal AGE and MDA levels, increases hippocampal SOD activity and GSH levels, and attenuates cognitive impairment in the Morris water maze in a mouse model of D-galactose-induced mild cognitive impairment

Formal name: (3β,6α,12β,24R)-20,24-epoxy-3,12,25-trihydroxydammaran-6-yl 2-O-(6-deoxy-α-L-mannopyranosyl)-β-D-glucopyranoside

Synonyms:  Ginsenoside A1

Molecular weight: 801

CAS: 69884-00-0

Purity: ≥98%

Formulation: A solid

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