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PSD95 Monoclonal Antibody (Clone 7E3) – 100 µg

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Cayman
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Postsynaptic Density protein 95 (PSD95), also known as synapse associated protein 90 kDa, is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. PSD95 is a scaffolding protein and is involved in the assembly and function of the postsynaptic density complex.{15697} These family members consist of an N-terminal variable segment followed by three amino-terminal PDZ domains, an upstream SH3 domain and an inactive carboxyl-terminal guanylate kinase (GK) domain. The first and second PDZ domains localize NMDA receptors and K+ channels to synapses, and the third binds to neuroligins, which are neuronal cell adhesion molecules that interact with β-neurexins and form intercellular junctions. PSD95 also binds to neuronal nitric oxide synthase, possibly through interactions between PDZ domains present on both proteins.{15699} Thus different PDZ domains of PSD95 might be specialized for distinct functions.{15700,15701} PSD95 participates in synaptic targeting of AMPA receptors through an indirect manner involving Stargazin and related transmembrane AMPA receptor regulatory proteins (TARPs).{15702} The protein is implicated in experience-dependent plasticity and plays an indispensable role in learning.{15703} Mutations in PSD95 are associated with autism.{15704}  

 

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SKU: 10011436 - 100 µg Category:

Description

Antigen: rat recombinant PSD95 · Host: mouse, clone 7E3 · Cross Reactivity: (+) mouse, rat and bovine PSD95 · Application: WB · Isotype: IgG2a

Synonyms: Postsynaptic Density Protein 95

Immunogen: rat recombinant PSD95

Formulation: Protein G affinity-purified in IgG, at a concentration of 1 mg/ml in PBS, pH 7.4, containing 0.09% sodium azide and 50% glycerol

Isotype: IgG2a

Applications: WB

Origin: Animal/Mouse

Stability: 365 days

Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Neuroscience|Behavioral Neuroscience|Learning & Memory

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