An adenosine A2B receptor antagonist (Ki = 53.4 nM); selective for A2B over A1 and A2A receptors

PSB-1115 (potassium salt) – 10 mg

Brand:
Cayman
CAS:
409344-71-4
Storage:
-20
UN-No:
Non-Hazardous - /

PSB-1115 is an antagonist of the adenosine A2B receptor (Ki = 53.4 nM).{40515} It is selective for A2B over A1 and A2A receptors, which have Ki values of 2,200 and 24,000 nM, respectively, and over the A3 receptor, which it inhibits only 14% at a concentration of 10 µM. PSB-1115 pre-treatment reduces relaxation of rat trachea induced by repeated dosing of the non-selective adenosine agonist NECA (Item No. 21420).{40516}  

 

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SKU: 23929 - 10 mg Category:

Description

An adenosine A2B receptor antagonist (Ki = 53.4 nM); selective for A2B over A1 and A2A receptors, which have Ki values of 2,200 and 24,000 nM, respectively; selective for A2B over the A3 receptor, which is inhibited only 14% at a concentration of 10 µM; pre-treatment of rat trachea reduces relaxation induced by repeated dosing of the non-selective adenosine agonist NECA

Formal name: 4-(2,3,6,9-tetrahydro-2,6-dioxo-1-propyl-1H-purin-8-yl)-benzenesulfonic acid, monopotassium salt

Synonyms: 

Molecular weight: 388.4

CAS: 409344-71-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Antagonists||Research Area

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