A potent inhibitor of IKKβ (IC50 = 88-100 nM); used to elucidate roles for NF-κB both in cells and in vivo

PS-1145 – 1 mg

Brand:
Cayman
CAS:
431898-65-6
Storage:
-20
UN-No:
Non-Hazardous - /

Nuclear factor-κB (NF-κB) is a protein complex which modulates gene transcription relevant to cellular responses to inflammation, stress, infection, and other factors.{19815} The inhibitor of NF-κB kinase β (IKKβ), in complex with IKKα and IKKγ, phosphorylates inhibitor of NF-κB A and B (IκA and IκB) and other proteins involved in NF-κB signaling, and thus plays a central regulatory role.{19815} PS-1145 is a potent inhibitor of IKKβ (IC50 = 88-100 nM).{23652,23654} Through this action, it is used to elucidate roles for NF-κB both in cells and in vivo.{23652,23651,23653,23650}  

 

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Description

A potent inhibitor of IKKβ (IC50 = 88-100 nM); used to elucidate roles for NF-κB both in cells and in vivo

Formal name: N-(6-chloro-9H-pyrido[3,4-b]indol-8-yl)-3-pyridinecarboxamide

Synonyms:  IKK Inhibitor X

Molecular weight: 322.8

CAS: 431898-65-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|IKKs||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Autoimmunity||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Immunology & Inflammation|Innate Immunity|STING||Research Area|Infectious Disease

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