A 5-HT2B receptor antagonist; binds to 5-HT2B receptors (Ki = 3.4 nM); inhibits 5-HT-induced MAPK activation and thymidine incorporation in CHO cells expressing human 5-HT2B (IC50s = ~12 and ~3 nM

PRX-08066 – 5 mg

Brand:
Cayman
CAS:
866206-54-4
Storage:
-20
UN-No:
Non-Hazardous - /

PRX-08066 is an antagonist of the serotonin (5-HT) receptor subtype 5-HT2B.{52798} It binds to 5-HT2B receptors (Ki = 3.4 nM) and inhibits 5-HT-induced MAPK activation and thymidine incorporation in CHO cells expressing human 5-HT2B (IC50s = ~12 and ~3 nM, respectively). PRX-08066 (50 and 100 mg/kg) reduces peak pulmonary arterial pressure and right ventricular hypertrophy in a rat model of pulmonary hypertension induced by monocrotaline (MCT; Item No. 16666).  

 

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SKU: 31477 - 5 mg Category:

Description

A 5-HT2B receptor antagonist; binds to 5-HT2B receptors (Ki = 3.4 nM); inhibits 5-HT-induced MAPK activation and thymidine incorporation in CHO cells expressing human 5-HT2B (IC50s = ~12 and ~3 nM, respectively); reduces peak pulmonary arterial pressure and right ventricular hypertrophy in a rat model of MCT-induced pulmonary hypertension at 50 and 100 mg/kg

Formal name: 5-[[4-[(6-chlorothieno[2,3-d]pyrimidin-4-yl)amino]-1-piperidinyl]methyl]-2-fluoro-benzonitrile

Synonyms: 

Molecular weight: 401.9

CAS: 866206-54-4

Purity: ≥95%

Formulation: A crystalline solid

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