A tricyclic antidepressant; binds to the norepinephrine and 5-HT transporters (Kd = 1.41 and 19.6 nM

Protriptyline (hydrochloride) – 50 mg

Brand:
Cayman
CAS:
1225-55-4
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Protriptyline is a tricyclic antidepressant.{22877} It binds to the norepinephrine and serotonin (5-HT) transporters with Kd values of 1.41 and 19.6 nM, respectively. Protriptyline also binds to histamine H1, muscarinic acetylcholine, and α1-adrenergic receptors (Kds = 25, 25, and 130 nM, respectively).{25914} It inhibits norepinephrine uptake into rat whole brain and hypothalamic synaptosomes (IC50s = 12 and 0.55 μM, respectively) and 5-HT uptake into rat whole brain synaptosomes (IC50 = 5.5 μM).{54252} Protriptyline (1 mg/kg, i.v.) inhibits food-induced cataplexy in narcoleptic dogs.{46726} Formulations containing protriptyline have been used in the treatment of depression.  

 

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Description

A tricyclic antidepressant; binds to the norepinephrine and 5-HT transporters (Kd = 1.41 and 19.6 nM, respectively); binds to histamine H1, muscarinic acetylcholine, and α1-adrenergic receptors (Kds = 25, 25, and 130 nM, respectively); inhibits norepinephrine uptake into rat whole brain and hypothalamic synaptosomes (IC50s = 12 and 0.55 μM, respectively) and 5-HT uptake into rat whole brain synaptosomes (IC50 = 5.5 μM); inhibits food-induced cataplexy in narcoleptic dogs at 1 mg/kg, i.v.

Formal name: N-methyl-5H-dibenzo[a,d]cycloheptene-5-propanamine, monohydrochloride

Synonyms:  Protryptyline

Molecular weight: 299.8

CAS: 1225-55-4

Purity: ≥98%

Formulation: A solid

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