An alkaloid with diverse biological activities; inhibits platelet aggregation induced by ADP

Protopine (hydrochloride) – 1 mg

Brand:
Cayman
CAS:
6164-47-2
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Protopine is an alkaloid found in Berberidaceae, Ranunculaceae, Rutaceae, Fumariaceae, and Papaveraceae with diverse biological activities.{41158} It inhibits platelet aggregation induced by ADP, arachidonic acid (Item Nos. 90010 | 90010.1 | 10006607), platelet-activating factor (PAF), and collagen in rabbit platelet-rich plasma at a concentration of 100 μM.{41159} Protopine inhibits contraction of isolated rat thoracic aorta induced by norepinephrine (Item No. 16673) and is a non-selective inhibitor of ICa, IK, IK1, and INa in guinea pig ventricular myocytes.{41160,41161} Protopine inhibits the growth of H. pylori with an MIC50 value of 100 μg/ml.{41162} It reduces growth of PC3 and DU145 prostate cancer cells in a dose-dependent manner via induction of mitotic cell cycle arrest.{41163} Protopine (0.005 mg/kg) increases latency to first seizure in a mouse model induced by pentylenetetrazole (Item No. 18682).{41164}  

 

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SKU: 23366 - 1 mg Category:

Description

An alkaloid with diverse biological activities; inhibits platelet aggregation induced by ADP, arachidonic acid, PAF, and collagen; inhibits norepinephrine-induced contraction of isolated rat thoracic aorta; a non-selective inhibitor of ICa, IK, IK1, and INa in guinea pig ventricular myocytes; inhibits the growth of H. pylori (MIC50 = 100 μg/ml); reduces growth of PC3 and DU145 prostate cancer cells in a dose-dependent manner via induction of mitotic cell cycle arrest; increases latency to first seizure in a pentylenetetrazole-induced mouse model

Formal name: 4,6,7,14-tetrahydro-5-methyl-bis[1,3]benzodioxolo[4,5-c:5′,6′-g]azecin-13(5H)-one, monohydrochloride

Synonyms: 

Molecular weight: 389.8

CAS: 6164-47-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Ion Channel Modulation|Blockers||Product Type|Biochemicals|Natural Products|Alkaloids||Research Area|Cancer|Cell Cycle|G2/M||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Cardiovascular System|Blood|Thrombosis||Research Area|Cardiovascular System|Vasculature|Vasodilation||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases||Research Area|Neuroscience|Seizure Disorders

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