A bactericidal thioamide effective against M. tuberculosis (MIC = ~0.5 µg/ml)

Prothionamide – 500 mg

Brand:
Cayman
CAS:
14222-60-7
Storage:
-20
UN-No:
Non-Hazardous - /

Prothionamide is a bactericidal thioamide effective against M. tuberculosis (MIC = ~0.5 µg/ml), M. leprae (MIC = 0.8-1.6 mg/L), and M. avium.{26434} It forms a covalent adduct with nicotinamide adenine dinucleotide that inhibits mycobacterial InhA, the enoyl-acyl ACP reductase involved in mycolic acid biosynthesis, with a Ki value of 2 nM.{26434}  

 

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Description

A bactericidal thioamide effective against M. tuberculosis (MIC = ~0.5 µg/ml), M. leprae (MIC = 0.8-1.6 mg/L), and M. avium; inhibits mycolic acid biosynthesis (Ki = 2 nM)

Formal name: 2-propyl-4-pyridinecarbothioamide

Synonyms:  Tebeform

Molecular weight: 180.3

CAS: 14222-60-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antibiotics||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Bacterial Diseases|Leprosy||Research Area|Infectious Disease|Bacterial Diseases|Tuberculosis

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