A specialized pro-resolving mediator; increases macrophage phagocytosis of PMNs in vitro and after 24 hours in vivo in mice; decreases PMN infiltration in a zymosan-induced mouse model of inflammation at 300 ng per animal; inhibits increases in neutrophil counts in BALF and lung myeloperoxidase activity in an LPS-induced mouse model of pulmonary injury and inflammation

Protectin D1 – 50 µg

Brand:
Cayman
CAS:
660430-03-5
Storage:
-80
UN-No:
De Minimis - 1170 / 3

Protectin D1 is a specialized pro-resolving mediator (SPM) synthesized from docosahexaenoic acid (DHA; Item No. 90310).{38180} DHA is oxidized to 16S,17S-epoxy-protectin, which is converted to protectin D1 enzymatically. Protectin D1 increases phagocytosis of apoptotic polymorphonuclear leukocytes (PMNs) by macrophages in a non-phlogistic manner and is generated in vitro during macrophage-apoptotic interactions.{14972} It enhances phagocytosis in mice after 24 hours, but not at the initiation or peak of inflammation. It also decreases PMN infiltration in a zymosan-induced mouse model of inflammation when administered at a dose of 300 ng per animal. Protectin D1 (200 µg, i.v.) inhibits increases in neutrophil counts in bronchoalveolar fluid (BALF) and lung myeloperoxidase activity in a mouse model of pulmonary injury and inflammation induced by intratracheal LPS instillation.{48017} It also decreases pulmonary edema and promotes neutrophil apoptosis in BALF.  

 

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SKU: 10010390 - 50 µg Category:

Description

A specialized pro-resolving mediator; increases macrophage phagocytosis of PMNs in vitro and after 24 hours in vivo in mice; decreases PMN infiltration in a zymosan-induced mouse model of inflammation at 300 ng per animal; inhibits increases in neutrophil counts in BALF and lung myeloperoxidase activity in an LPS-induced mouse model of pulmonary injury and inflammation

Formal name: 10R,17S-dihydroxy-4Z,7Z,11E,13E,15Z,19Z-docosahexaenoic acid

Synonyms:  Neuroprotectin D1|Neuroprotectin D1/Protectin D1|NPD1|PD1

Molecular weight: 360.5

CAS: 660430-03-5

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Docosanoids||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Specialized Pro-Resolving Mediators||Research Area|Immunology & Inflammation|Innate Immunity|Phagocytosis||Research Area|Immunology & Inflammation|Pulmonary Diseases||Research Area|Lipid Biochemistry|Lipoxygenase Pathways

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