Description
A cell-permeable prodrug form of TAME; is converted to TAME by intracellular esterases; blocks association of APC/C with the activator CDH1 and inhibits degradation of APC/C substrates in HeLa cells at 12 μM; induces mitotic arrest in metaphase followed by cell death in synchronized HeLa H2B-GFP cells at 12 μM; increases mitotic duration in asynchronous HeLa H2B-GFP at 4 μM, an effect that is enhanced by knockdown of the APC/C co-activator CDC20; decreases the viability of several laboratory and primary patient-derived human MM cell lines (IC50s = 2.8-20.3 μM); increases apoptosis in RPMI-8226, LP-1, NCI-H929, and U266 MM cells at 12 μM
Formal name: (2S)-2-[[(4-methylphenyl)sulfonyl]amino]-9,13-dioxo-14-phenyl-7-[[[[(2-phenylacetyl)oxy]methoxy]carbonyl]amino]-10,12-dioxa-6,8-diazatetradec-6-enoic acid, methyl ester
Synonyms: Pro-N-4-tosyl-L-arginine methyl ester
Molecular weight: 726.8
CAS: 1362911-19-0
Purity: ≥90%
Formulation: A solution in DMSO
Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Cancer|Cell Cycle||Research Area|Cancer|Cell Death
