Potently induces HIV-1 reactivation in latent reservoirs of infected Jurkat-LAT-GFP cells (IC50 = ~0.5 µM); activates NF-κB via PKC and downregulates HIV-1 receptor CD4 expression and its co-receptors CXCR4 and CCR5

Prostratin – 10 mg

Brand:
Cayman
CAS:
60857-08-1
Storage:
-20
UN-No:
Non-Hazardous - /

Activation of latent reservoirs of HIV-infected cells is a treatment strategy designed to reduce viral load and eliminate the perpetuation of retroviral infection. Prostratin is a non-tumor promoting phorbol ester that potently induces HIV-1 reactivation in latent reservoirs of infected Jurkat-LAT-GFP cells with an IC50 value of ~0.5 µM.{17117} Originally, prostratin was isolated from plant sources including P. prostrata, E. cornigera, and H. nutans. {15812} The effects of prostratin are mediated through activation of NF-κB via protein kinase C and by downregulation of HIV-1 receptor CD4 expression and its co-receptors CXCR4 and CCR5.{17116,17118,17119}  

 

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SKU: 10272 - 10 mg Category:

Description

Potently induces HIV-1 reactivation in latent reservoirs of infected Jurkat-LAT-GFP cells (IC50 = ~0.5 µM); activates NF-κB via PKC and downregulates HIV-1 receptor CD4 expression and its co-receptors CXCR4 and CCR5

Formal name: 9a-(acetyloxy)-1,1aR,1bS,4,4aR,7aS,7bR,8R,9,9aS-decahydro-4a,7b-dihydro-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5H-cyclopropa[3,4]benz[1,2-e]azulen-5-one

Synonyms:  13-O-Acetylphorbol|NSC 623310|SA 101A

Molecular weight: 390.5

CAS: 60857-08-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products||Product Type|Biochemicals|Receptor Pharmacology||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Viral Diseases|HIV & AIDS

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