A dehydration product of PGD2 formed by the elimination of the C-9 hydroxyl group; inhibits platelet aggregation (IC50 ~ 5-10 nM); has antimitotic and antiproliferative effects on a variety of cultured normal cells and tumor cell lines

Prostaglandin J2 – 1 mg

Brand:
Cayman
CAS:
60203-57-8
Storage:
-80
UN-No:
De Minimis - 1231 / 3

Prostaglandin J2 (PGJ2) is formed from PGD2 by the elimination of the C-9 hydroxyl group, a process which is accelerated by the presence of albumin.{1742} PGJ2 inhibits platelet aggregation with an IC50 of about 5-10 nM.{1139,504} PGJ2 has antimitotic and antiproliferative effects on a variety of cultured normal cells and tumor cell lines.{870} However, this activity has been attributed to further metabolites of PGJ2 and not the parent compound itself.  

 

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Description

A dehydration product of PGD2 formed by the elimination of the C-9 hydroxyl group; inhibits platelet aggregation (IC50 ~ 5-10 nM); has antimitotic and antiproliferative effects on a variety of cultured normal cells and tumor cell lines

Formal name: 11-oxo-15S-hydroxy-prosta-5Z,9,13E-trien-1-oic acid

Synonyms:  PGJ2

Molecular weight: 334.5

CAS: 60203-57-8

Purity: ≥95%

Formulation: A solution in methyl acetate

Product Type|Biochemicals|Lipids|Prostaglandins||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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