A metabolite of AEA that is formed by the sequential actions of COX-2 and PGF synthase; reported to be biosynthesized by this mechanism when AEA was infused into the lung and liver of living mice

Prostaglandin F2α Ethanolamide – 1 mg

Brand:
Cayman
CAS:
353787-70-9
Storage:
-20
UN-No:
De Minimis - 1170 / 3

Prostaglandin F2α ethanolamide (PGF2α-EA) is produced by COX-2 metabolism of the endogenous cannabinoid, arachidonoyl ethanolamide (AEA), found in brain, liver, and other mammalian tissues.{2415} AEA can be metabolized directly by the sequential action of COX-2 and specific PG synthases to produce ethanolamide congeners of the classical PGs.{5089,11045} PGF2α-EA has also been reported to be biosynthesized by this mechanism when AEA was infused into the lung and liver of living mice. PGF2α-EA is a potent dilator (EC50 = 58 nM) of the cat iris sphincter, which is a model system for testing potential intraocular hypotensive agents.{8671}  

 

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Description

A metabolite of AEA that is formed by the sequential actions of COX-2 and PGF synthase; reported to be biosynthesized by this mechanism when AEA was infused into the lung and liver of living mice

Formal name: N-(2-hydroxyethyl)-9α,11α,15S-trihydroxy-prosta-5Z,13E-dien-1-amide

Synonyms:  Dinoprost Ethanolamide|PGF2α-EA

Molecular weight: 397.5

CAS: 353787-70-9

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Prostaglandins||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Neuroscience|Cannabinoid Research|Endocannabinoids||Research Area|Neuroscience|Ophthalmology

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