2-Arachidonoyl glycerol (2-AG; Item No. 62160) has been isolated from porcine brain

Prostaglandin F2α-1-glyceryl ester – 1 mg

Brand:
Cayman
CAS:
43042-79-1
Storage:
-20
UN-No:
De Minimis - 1170 / 3

2-Arachidonoyl glycerol (2-AG; Item No. 62160) has been isolated from porcine brain, and has been characterized as the natural endocannabinoid ligand for the central cannabinoid receptor.{4614,5306} Incubation of 2-AG with cyclooxygenase-2 and specific prostaglandin H2 (PGH2) isomerases in cell cultures and isolated enzyme preparations results in PG glyceryl ester formation.{11045} The biosynthesis of PGH, PGD, PGE, PGF, and thromboxane A-2-glyceryl ester compounds have all been documented. The 2-glyceryl ester moiety equilibrates rapidly (within minutes) with the more stable 1-glyceryl ester, producing a 10:90 2:1-glyceryl ester mixture in typical aqueous media. While the stability and metabolism of PGF2α-1-glyceryl ester has been investigated, little is known about its intrinsic biological activity.{10555}  

 

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Description

2-Arachidonoyl glycerol (2-AG; Item No. 62160) has been isolated from porcine brain,{4614} and has been characterized as the natural endocannabinoid ligand for the CB1 receptor.{5306} Incubation of 2-AG with COX-2 and specific PGH2 isomerases in cell cultures and isolated enzyme preparations results in prostaglandin glyceryl ester formation.{11045} The biosynthesis of PGH, PGD, PGE, PGF, and TXA-2-glyceryl ester compounds have all been documented. The 2-glyceryl ester moiety equilibrates rapidly (within minutes) with the more stable 1-glyceryl ester, producing a 10:90 2:1-glyceryl ester mixture in typical aqueous media. While the stability and metabolism of PGF2α-1-glyceryl ester has been investigated,{10555} little is known about its intrinsic biological activity.

Formal name: 9α,11α,15S-trihydroxy-prosta-5Z,13E-dien-1-oic acid, 1-glyceryl ester

Synonyms:  PGF2α-1-glyceryl ester

Molecular weight: 428.6

CAS: 43042-79-1

Purity: ≥98% (as a 9:1 mixture of the 2- and 1-glyceryl esters)

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Prostaglandins||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Lipid Biochemistry|Endocannabinoid/Endocannabinoid-like||Research Area|Neuroscience|Cannabinoid Research|Endocannabinoids

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