A quantitative analytical standard guaranteed to meet MaxSpec® identity

Prostaglandin E2 Ethanolamide MaxSpec® Standard – 100 µg

Brand:
Cayman
CAS:
194935-38-1
Storage:
-20
UN-No:
Non-Hazardous - 1170 / 3

Prostaglandin E2 ethanolamide (PGE2-EA) is an analog of PGE2 (Item No. 14010) with improved water solubility and stability. PGE2-EA is formed via COX-2 metabolism of arachidonoyl ethanolamide (AEA; Item No. 90050) and acts as an agonist at E prostanoid (EP) receptors 1-4 (Kis = 2.45, 0.46, 0.2, and 0.51 μM, respectively).{11045,10926} It also inhibits indoleamine 2,3-dioxygenase-1 (IDO-1) in THP-1 cells and human monocytes (IC50s = 5.7 and 4.7 μM, respectively).{40333} PGE2-EA (10 μM) prevents morphological changes and F-actin rearrangement as well as reduces L-homocysteine-induced NLRP3 inflammasome formation and activation in podocytes.{41626} Ex vivo, PGE2-EA reduces luminal damage and lymphocyte infiltration in a human mucosal explant colitis model.{41627} PGE2-EA MaxSpec® standard is a quantitative grade standard of PGE2-EA (Item No. 14012) that has been prepared specifically for mass spectrometry or any application where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. This PGE2-EA MaxSpec® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.  

 

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SKU: 10007212 - 100 µg Category:

Description

A quantitative analytical standard guaranteed to meet MaxSpec® identity, purity, stability, and concentration specifications,

Formal name: N-(2-hydroxyethyl)-9-oxo-11α,15S-dihydroxy-prosta-5Z,13E-dien-1-amide

Synonyms:  Dinoprostone Ethanolamide|PGE2-EA|Prostamide E2

Molecular weight: 395.5

CAS: 194935-38-1

Purity: ≥95%

Formulation: A solution in ethanol at 100 µg/ml

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards|MaxSpec®||Product Type|Biochemicals|Lipids|Prostaglandins||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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