A non-irritant bronchodilator with relaxant activity on human bronchial muscle; binds to the mouse recombinant EP3 and EP4 receptors with Ki values of 330 and 190 nM

Prostaglandin E1 Alcohol – 10 mg

Brand:
Cayman
CAS:
21562-57-2
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

Prostaglandin E1 (PGE1) alcohol is a non-irritant bronchodilator, with relaxant activity on the human bronchial muscle in vitro, comparable to PGE1 at concentrations of 0.01 to 10.0 µg/ml.{2118,2119} Asthmatics receiving single dose inhalation treatments reported significant but short-acting bronchodilation at doses of 10 and 30 µg.{2118} PGE1 alcohol binds to the mouse recombinant EP3 and EP4 receptors with Ki values of 330 and 190 nM, respectively.{6640}  

 

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Description

A non-irritant bronchodilator with relaxant activity on human bronchial muscle; binds to the mouse recombinant EP3 and EP4 receptors with Ki values of 330 and 190 nM, respectively

Formal name: 1,11α,15S-trihydroxy-prost-13E-en-9-one

Synonyms:  1-hydroxy Prostaglandin E1|PGE1 Alcohol

Molecular weight: 340.5

CAS: 21562-57-2

Purity: ≥99%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Prostaglandins||Product Type|Biochemicals|Receptor Pharmacology||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Immunology & Inflammation|Pulmonary Diseases|Asthma||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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