Description
Prostaglandin E synthase (PGES) catalyzes the isomerization of PGH2 (Item No. 17020) to PGE2 (Item No. 14010). Cytosolic and microsomal PGES enzymes have been cloned and characterized. Cytosolic PGES (cPGES) is a glutathione-dependent enzyme with a predicted size of 18.6 kDa (23 kDa on SDS-PAGE). The enzyme is expressed in a wide variety of tissues and cells, the levels of which are unaffected by treatment with IL-1β and TNF-α.{8691} However, enzyme expression increases approximately 3-fold in rat brain following LPS treatment.{8691} Microsomal PGES (mPGES) is a 16 kDa protein expressed in a variety of tissues including prostate, testes, and small intestine, as well as in A549 and HeLa cells.{7229} In contrast to cPGES, mPGES protein expression is increased in A549 cells following treatment with IL-1β.{7229} The two enzymes show <10% homology at the amino acid level.
Synonyms: cPGE Synthase|cPGES|Hsp90 Co-chaperone|p23|Teolomerate-binding protein p23
Immunogen: Synthetic peptide from an internal region of human protein cPGES synthase
Formulation: Lyophilized, peptide affinity-purified antibody
Isotype:
Applications: WB
Origin: Animal/Rabbit
Stability: 365 days
Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Polyclonal Antibodies||Research Area|Cancer||Research Area|Endocrinology & Metabolism|Reproductive Biology||Research Area|Immunology & Inflammation||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway
