2-Arachidonyl glycerol (2-AG) exhibits CB agonist activity at the CB1 receptor

Prostaglandin D2 serinol amide – 5 mg

Brand:
Cayman
CAS:
851761-42-7
Storage:
-20
UN-No:
De Minimis - 1170 / 3

2-Arachidonyl glycerol (2-AG) exhibits cannabinoid (CB) agonist activity at the CB1 receptor,{5306} is an important endogenous monoglyceride species,{6819} and is thus considered to be the natural ligand for the CB1 receptor. 2-AG can also be sequentially metabolized by COX-2 and specific PG synthases to form PG 2-glyceryl esters.{11045} In activated RAW 264.7 cells, PGD2 2-glyceryl ester is the primary product of 2-AG metabolism in the COX pathway.{11045} PGD2 serinol amide (PGD2-SA) is a stable analog of PGD2 2-glyceryl ester. Unlike PGD2 2-glyceryl ester and other fatty acyl 2-glyceryl esters, PGD2-SA will not isomerize to the less active primary (1-glyceryl) ester. The biological activity of PGD2-SA has not yet been determined.  

 

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SKU: 10192 - 5 mg Category:

Description

2-Arachidonyl glycerol (2-AG) exhibits CB agonist activity at the CB1 receptor,{5306} is an important endogenous monoglyceride species,{6819} and is thus considered to be the natural ligand for the CB1 receptor. 2-AG can also be metabolized by COX-2 to form PG 2-glyceryl esters.{11045} In activated RAW 264.7 cells, PGD2 2-glyceryl ester is the primary product of 2-AG metabolism in the COX pathway.{11045} PGD2-SA is a stable analog of PGD2 2-glyceryl ester. Unlike PGD2 2-glyceryl ester and other fatty acyl 2-glyceryl esters, PGD2-SA will not isomerize to the less active primary (1-glyceryl) ester. The biological activity of PGD2-SA has not yet been determined.

Formal name: N-[(2-hydroxy-1-hydroxymethyl)ethyl]-11-oxo-9α,15S-dihydroxy-prosta-5Z,13E-dien-1-amide

Synonyms:  PGD2-SA

Molecular weight: 425.6

CAS: 851761-42-7

Purity: ≥98%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Prostaglandins||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Lipid Biochemistry|Endocannabinoid/Endocannabinoid-like||Research Area|Neuroscience|Cannabinoid Research

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