A bioactive lipid produced by the sequential metabolism of anandamide by COX enzymes and PGD synthase; inactive against recombinant prostanoid receptors

Prostaglandin D2 Ethanolamide – 500 µg

Brand:
Cayman
CAS:
398138-28-8
Storage:
-80
UN-No:
Non-Hazardous - /

Prostaglandin D2 ethanolamide (PGD2-EA) is a bioactive lipid produced by the sequential metabolism of anandamide (arachidonoyl ethanolamide) by cyclooxygenase (COX) enzymes, in particular by COX-2, and PGD synthase.{11045,22752,22753} The biosynthesis of PGD2-EA from anandamide can also be increased when anandamide metabolism is diminished by deletion of fatty acid amide hydrolase.{12142} PGD2-EA is inactive against recombinant prostanoid receptors, including the D prostanoid receptor.{12144} It increases the frequency of miniature inhibitory postsynaptic currents in primary cultured hippocampal neurons, an effect which is the opposite of that induced by anandamide.{22753}. PGD2-EA also induces apoptosis in colorectal carcinoma cell lines.{22752}  

 

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SKU: 12012 - 500 µg Category:

Description

A bioactive lipid produced by the sequential metabolism of anandamide by COX enzymes and PGD synthase; inactive against recombinant prostanoid receptors, including DP; increases the frequency of miniature inhibitory postsynaptic currents in hippocampal neurons; induces apoptosis in colorectal carcinoma cell lines

Formal name: N-(2-hydroxyethyl)-11-oxo-9α,15S-dihydroxy-prosta-5Z,13E-dien-1-amide

Synonyms:  PGD2-EA|Prostamide D2

Molecular weight: 395.5

CAS: 398138-28-8

Purity: ≥96%

Formulation: A solution in ethanol

Product Type|Biochemicals|Lipids|Prostaglandins||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Lipid Biochemistry|Endocannabinoid/Endocannabinoid-like||Research Area|Neuroscience|Cannabinoid Research|Endocannabinoids

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