The major eicosanoid product of mast cells released in large quantities during allergic and asthmatic anaphylaxis; also produced in the brain via an alternative pathway involving a soluble

Prostaglandin D2 – 10 mg

Brand:
Cayman
CAS:
41598-07-6
Storage:
-20
UN-No:
Non-Hazardous - /

Prostaglandin D2 (PGD2) is the major eicosanoid product of mast cells and is released in large quantities during allergic and asthmatic anaphylaxis.{416} Mastocytosis patients produce excessive amounts of PGD2, which causes vasodilation, flushing, hypotension, and syncopal episodes.{416} PGD2 is also produced in the brain via an alternative pathway involving a soluble, secreted PGD-synthase also known as β-trace.{328,1185} In the brain, PGD2 produces normal physiological sleep and lowering of body temperature.{328,1185} Further pharmacological actions include inhibition of platelet aggregation and relaxation of vascular smooth muscle.{580} PGD2 inhibits human ovarian tumor cell proliferation with an IC50 of 6.8 µM.{1349}  

 

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SKU: 12010 - 10 mg Category:

Description

The major eicosanoid product of mast cells released in large quantities during allergic and asthmatic anaphylaxis; also produced in the brain via an alternative pathway involving a soluble, secreted PGD-synthase also known as β-trace where it induces normal physiological sleep and lowering of body temperature; inhibits platelet aggregation, relaxes vascular smooth muscle, and inhibits human ovarian tumor cell proliferation (IC50 = 6.8 µM)

Formal name: 9α,15S-dihydroxy-11-oxo-prosta-5Z,13E-dien-1-oic acid

Synonyms:  PGD2

Molecular weight: 352.5

CAS: 41598-07-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Prostaglandins||Research Area|Cardiovascular System|Blood|Coagulation & Hemostasis||Research Area|Cardiovascular System|Cardiovascular Diseases|Hypotension||Research Area|Cardiovascular System|Vasculature|Vasodilation||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Inflammatory Lipid Mediators|Prostaglandins||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Immunology & Inflammation|Pulmonary Diseases|Asthma||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway||Research Area|Neuroscience|Behavioral Neuroscience|Sleep & Biological Rhythms

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