Cyclooxygenase metabolism of EPA to produce PGE3 has been reported in biosynthetic preparations of ovine seminal vesicles{963} and in the ocular tissues of primates.{1144} PGA3 is an expected non-enzymatic dehydration product of this PGE3. PGA3 exhibits good affinity for the canine EP2 and EP4 receptors with IC50 values of 120 nM and 20 nM

Prostaglandin A3 – 50 µg

Brand:
Cayman
CAS:
36614-31-0
Storage:
-20
UN-No:
De Minimis - 1231 / 3

Cyclooxygenase metabolism of EPA to produce Prostaglandin E3 (PGE3) has been reported in biosynthetic preparations of ovine seminal vesicles{963} and in the ocular tissues of primates.{1144} Prostaglandin A3 (PGA3) is an expected non-enzymatic dehydration product of this PGE3. PGA3 exhibits good affinity for the canine EP2 and EP4 receptors with IC50 values of 120 nM and 20 nM, respectively, in a radioligand binding assay.{11147,11148} PGA3 has weak affinity for human PPARγ, with a Ki value of 188 µM.{11138}  

 

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SKU: 10310 - 50 µg Category:

Description

Cyclooxygenase metabolism of EPA to produce PGE3 has been reported in biosynthetic preparations of ovine seminal vesicles{963} and in the ocular tissues of primates.{1144} PGA3 is an expected non-enzymatic dehydration product of this PGE3. PGA3 exhibits good affinity for the canine EP2 and EP4 receptors with IC50 values of 120 nM and 20 nM, respectively, in a radioligand binding assay.{11147,11148} PGA3 has weak affinity for human PPARγ, with a Ki value of 188 µM.{11138}

Formal name: 9-oxo-15S-hydroxy-prosta-5Z,10,13E,17Z-tetraen-1-oic acid

Synonyms:  PGA3

Molecular weight: 332.4

CAS: 36614-31-0

Purity: ≥98%

Formulation: A solution in methyl acetate

Product Type|Biochemicals|Lipids|Prostaglandins||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Lipid Biochemistry|Cyclooxygenase Pathway

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