An antithyroid agent; inhibits thyroid peroxidase activity in rat and monkey thyroid microsomes (IC50s = 0.081 and 4.1 μM

Propylthiouracil – 50 g

Brand:
Cayman
CAS:
51-52-5
Storage:
-20
UN-No:
Non-Hazardous - /

Propylthiouracil (PTU) is a thioamide antithyroid agent.{52763} It inhibits thyroid peroxidase activity in rat and monkey thyroid microsomes (IC50s = 0.081 and 4.1 μM, respectively). PTU (30 mg/kg) increases thyroid weight and serum thyroid stimulating hormone levels and decreases serum 3,5,3′-triiodothyronine and thyroxine levels in rats. Sensitivity to the bitter taste of PTU is genetically mediated and is associated with increased sensitivity to other sweet and bitter compounds.{22286} Formulations containing propylthiouracil have been used in the treatment of Graves’ disease and hyperthyroidism.  

 

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Description

An antithyroid agent; inhibits thyroid peroxidase activity in rat and monkey thyroid microsomes (IC50s = 0.081 and 4.1 μM, respectively); increases thyroid weight and serum thyroid stimulating hormone levels and decreases serum 3,5,3’-triiodothyronine and thyroxine levels in rats at 30 mg/kg; sensitivity to the bitter taste of PTU is genetically mediated and is associated with increased sensitivity to other sweet and bitter compounds

Formal name: 2,3-dihydro-6-propyl-2-thioxo-4(1H)-pyrimidinone

Synonyms:  6-n-Propylthiouracil|NSC 6498|NSC 70461|PTU

Molecular weight: 170.2

CAS: 51-52-5

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Thyroid Hormones

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