A promazine neuroleptic and dopamine receptor antagonist; an antagonist at the tick and mosquito dopamine receptors

Propionylpromazine (hydrochloride) – 250 mg

Brand:
Cayman
CAS:
7681-67-6
Storage:
-20
UN-No:
Non-Hazardous - /

Propionylpromazine is a promazine neuroleptic and dopamine receptor antagonist.{61016, 61012, 61013} It is an antagonist at the I. scapularis (tick) dopamine 2 receptor (Isdop2) and A. aegypti (mosquito) dopamine 2 receptor (AaDOP2), providing 94 and 85% inhibition, respectively, in a chemical screening assay at 10 µM.{61012, 61013} Propionylpromazine inhibits recombinant T. cruzi trypanothione reductase (IC50 = 357 µM) and is active against T. brucei trypomastigotes (ED50 = 10.1 µM) but not L. donovani amastigotes or T. cruzi trypomastigotes (ED50s = >30 µM) in mouse peritoneal macrophages.{61014} It increases survival of C. elegans in a model of paraquat-induced oxidative stress.{61015} Propionylpromazine reduces stereotypic behavior induced by apomorphine in rats (ED50 = 2.5 mg/kg, s.c.).{61016} Formulations containing propionylpromazine have been used as tranquilizers in veterinary medicine.  

 

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SKU: 31470 - 250 mg Category:

Description

A promazine neuroleptic and dopamine receptor antagonist; an antagonist at the tick and mosquito dopamine receptors, Isdop2 and AaDOP2, providing 94 and 85% inhibition, respectively, in a chemical screening assay at 10 µM; inhibits recombinant T. cruzi trypanothione reductase (IC50 = 357 µM) and is active against T. brucei trypomastigotes (ED50 = 10.1 µM) in mouse peritoneal macrophages; increases survival of C. elegans in a model of paraquat-induced oxidative stress

Formal name: 1-[10-[3-(dimethylamino)propyl]-10H-phenothiazin-2-yl]-1-propanone, monohydrochloride

Synonyms: 

Molecular weight: 376.9

CAS: 7681-67-6

Purity: ≥93%

Formulation: A solid

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