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Progesterone Receptor (Phospho-Ser294) Monoclonal Antibody – 1 ea

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Cayman
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There is accumulating evidence to suggest that progesterone plays an essential role in the regulation of growth and differentiation of mammary glands and thus may play a key role in breast cancer.{14655} The biological response to progesterone is mediated by two distinct forms of the human progesterone receptor (PR-A and PR-B forms). In most cell contexts, the B form functions as a transcriptional activator, whereas the A form functions as a transcriptional inhibitor of steroid hormones.{14653,14656} Recently it has been demonstrated that there is differential hormone dependent regulation of the phosphorylation of the A and B forms of the receptor.{14654} Treatment of T47D breast cancer cells with progestin agonist increases the phosphorylation of Ser190 and Ser294 with different kinetics. These phosphorylation events may differentially affect the transcriptional activity of the receptor.  

 

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SKU: 10009763 - 1 ea Category:

Description

Antigen: phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser294 of human progesterone receptor · Host: mouse · Cross-reactivity: (+) human progesterone receptor; expected to react with mouse, rat, non-human primates progesterone receptor based on 100% homology with the amino acid sequence used as the antigen · Application: WB and IHC (frozen sections)

Synonyms:

Immunogen: phosphopeptide corresponding to amino acid residues surrounding the phospho-Ser294 of human progesterone receptor

Formulation: Peptide affinity-purified antibody

Isotype:

Applications: WB and IHC (frozen sections)

Origin: Animal/Mouse

Stability: 365 days

Application|Immunohistochemistry||Application|Western Blot||Product Type|Antibodies|Monoclonal Antibodies||Research Area|Cancer||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Estrogens & Progestins||Research Area|Endocrinology & Metabolism|Reproductive Biology

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