A prodrug form of cysteine with antioxidant activity; reduces TNF-α-induced increases in IL-6 and CCL2 expression in ARPE-19 human retinal pigment epithelial cells at 0.5 mM; increases liver GSH levels in fasted

Procysteine – 5 g

Brand:
Cayman
CAS:
19771-63-2
Storage:
-20
UN-No:
Non-Hazardous - /

Procysteine is a prodrug form of cysteine that is metabolized to cysteine intracellularly and has antioxidant activity.{58119,58120} It reduces TNF-α-induced increases in the expression of IL-6 and chemokine (C-C motif) ligand 2 (CCL2) in ARPE-19 human retinal pigment epithelial cells when used at a concentration of 0.5 mM.{58121} Procysteine (6.5 mmol/kg) also increases liver glutathione (GSH) levels in fasted, but not fed, mice.{58119} It reduces the production of reactive oxygen species (ROS) in bronchoalveolar lavage fluid (BALF) and decreases plasma extravasation in the lungs, as well as reverses decreases in the levels of hypoxia-inducible factor (HIF-1α) in a mouse model of allergic asthma when administered at doses of 80 and 160 mg/kg.{58120}  

 

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SKU: 10006326 - 5 g Category:

Description

A prodrug form of cysteine with antioxidant activity; reduces TNF-α-induced increases in IL-6 and CCL2 expression in ARPE-19 human retinal pigment epithelial cells at 0.5 mM; increases liver GSH levels in fasted, but not fed, mice at 6.5 mmol/kg; reduces ROS production in BALF and decreases plasma extravasation in the lungs, as well as reverses decreases in HIF-1α levels in a mouse model of allergic asthma at 80 and 160 mg/kg

Formal name: 2-oxo-(4R)-4-thiazolidinecarboxylic acid

Synonyms:  L-2-oxothiazolidine-4-carboxylate|L-2-oxothiazolidine-4-carboxylic acid|OTC

Molecular weight: 147.2

CAS: 19771-63-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Allergy||Research Area|Immunology & Inflammation|Pulmonary Diseases|Asthma||Research Area|Oxidative Stress & Reactive Species|Antioxidant Activity||Research Area|Oxidative Stress & Reactive Species|Reactive Oxygen||Research Area|Oxidative Stress & Reactive Species|Reactive Sulfur|Glutathione

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