A polyphenol flavonoid dimer of (+)-catechin and (−)-epicatechin; inhibits hepatitis C virus RNA replication (EC50 = 72 µM); prevents phosphorylation of ERK1/2 and the production of ROS in THP-1 cells at 10 µg/ml; decreases TNF-α

Procyanidin B1 – 1 mg

Brand:
Cayman
CAS:
20315-25-7
Storage:
-20
UN-No:
Non-Hazardous - /

Procyanidin B1 is a polyphenol flavonoid existing as a dimer of (+)-catechin (Item No. 70940) and (−)-epicatechin (Item No. 11807). It inhibits hepatitis C virus RNA replication (EC50 = 72 µM), while (+)-catechin and (−)-epicatechin do not, up to concentrations of 200 µM.{34659} Procyanidin C1 (10 µg/ml) prevents phosphorylation of ERK1/2 and the production of reactive oxygen species (ROS) in THP-1 cells.{34660} It decreases TNF-α, phosphorylated p38 MAPK, and NF-κB levels following LPS administration.{34661}  

 

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Description

A polyphenol flavonoid dimer of (+)-catechin and (−)-epicatechin; inhibits hepatitis C virus RNA replication (EC50 = 72 µM); prevents phosphorylation of ERK1/2 and the production of ROS in THP-1 cells at 10 µg/ml; decreases TNF-α, phosphorylated p38 MAPK, and NF-κB levels after LPS administration

Formal name: (2R,2’R,3R,3’S,4R)-2,2′-bis(3,4-dihydroxyphenyl)-3,3′,4,4′-tetrahydro-[4,8′-bi-2H-1-benzopyran]-3,3′,5,5′,7,7′-hexol

Synonyms:  (−)-Epicatechin-(4β-8)-(+)-catechin|Proanthocyanidin B1|Procyanidol B1

Molecular weight: 578.5

CAS: 20315-25-7

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Antivirals||Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Natural Products|Polyphenols||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Product Type|Biochemicals|Small Molecule Inhibitors|TNF-α/NF-κB Signaling||Research Area|Immunology & Inflammation|Innate Immunity||Research Area|Infectious Disease|Viral Diseases|Hepatitis

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