A flavanol dimer with diverse biological properties; scavenges DPPH radicals (IC50 = 5.08 μM); inhibits PDGF-induced STAT3 activation in primary rat VSMCs at 30 μg/ml; inhibits growth of S. aureus and E. coli (MICs = 62.5 and 62.5 μg/ml

Procyanidin A2 – 5 mg

Brand:
Cayman
CAS:
41743-41-3
Storage:
-20
UN-No:
Non-Hazardous - /

Procyanidin A2 is a natural flavanol dimer of (–)–epicatechin (Item No. 11807) that is found in the horse chestnut (A. hippocastanum), mountain cranberry (V. vitis-idaea), and other fruits with antioxidant, anti-inflammatory, antibacterial, antiproliferative, and antidiabetic properties.{39743,39744,39745,39746,39747} It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; Item No. 14805) radicals (IC50 = 5.08 μM) and inhibits STAT3 activation induced by platelet derived growth factor (PDGF) in primary rat vascular smooth muscle cells (VSMCs) when used at a concentration of 30 μg/ml.{39745,39746} Procyanidin A2 inhibits growth of S. aureus and E. coli (MICs = 62.5 and 62.5 μg/ml, respectively) and proliferation of human HepG2 liver hepatocellular carcinoma and HeLa cervical cancer cells (EC50s = 62.19 and 66.07 μg/ml, respectively).{39745} It also increases insulin secretion from primary mouse pancreatic islets when used at a concentration of 10 μM in vitro and inhibits bisphenol A-induced glucose increases in fasted mice when administered at a dose of 10 μmol/kg per day.{39747}  

 

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SKU: 25200 - 5 mg Category:

Description

A flavanol dimer with diverse biological properties; scavenges DPPH radicals (IC50 = 5.08 μM); inhibits PDGF-induced STAT3 activation in primary rat VSMCs at 30 μg/ml; inhibits growth of S. aureus and E. coli (MICs = 62.5 and 62.5 μg/ml, respectively) and proliferation of human HepG2 liver hepatocellular carcinoma and HeLa cervical cancer cells (EC50s = 62.19 and 66.07 μg/ml, respectively); increases insulin secretion from primary mouse pancreatic islets at 10 μM; inhibits bisphenol A-induced glucose increases in fasted mice at 10 μmol/kg per day

Formal name: (2R,3R,8S,14R,15R)-2,8-bis(3,4-dihydroxyphenyl)-3,4-dihydro-8,14-methano-2H,14H-1-benzopyrano[7,8-d][1,3]benzodioxocin-3,5,11,13,15-pentol

Synonyms:  (+)-Epicatechin-(4β-8,2β-O-7)-epicatechin|Proanthocyanidin A2|Procyanidin dimer A2|Procyanidol A2

Molecular weight: 576.5

CAS: 41743-41-3

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Antibiotics||Product Type|Biochemicals|Natural Products|Flavonoids||Product Type|Biochemicals|Ox Stress Reagents|Antioxidants||Research Area|Cancer||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Immunology & Inflammation||Research Area|Infectious Disease

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