An adrenergic receptor agonist; selective for β2-ARs over β1-ARs (Kds = 46 and 4

Procaterol (hydrochloride) – 5 mg

Brand:
Cayman
CAS:
62929-91-3
Storage:
-20
UN-No:
Non-Hazardous - /

Procaterol is an agonist of β2-adrenergic receptors (β2-ARs).{47634} It binds to (Kd = 46 pM), and is selective for, β2-ARs over β1-ARs (Kd = 4,000 pM). Procaterol binds more potently to β2-ARs in isolated guinea pig lung than to β1-ARs in isolated guinea pig cardiac ventricle in the presence (IC50s = 175 and 1,660 nM, respectively) and absence of GTP (Item No. 16060; IC50s = 55.1 and 1,660 nM, respectively).{47635} It inhibits contractions induced by acetylcholine (Item No. 23829) in isolated guinea pig trachea (EC50 = 10.5 nM).{47636} In vivo, procaterol inhibits histamine-induced airflow obstruction in a guinea pig model of ovalbumin-sensitized asthma when administered via inhalation at a dose of 10 µg/ml.{47637}  

 

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Description

An adrenergic receptor agonist; selective for β2-ARs over β1-ARs (Kds = 46 and 4,000 pM, respectively); binds more potently to β2-ARs in isolated guinea pig lung than to β1-ARs in isolated guinea pig cardiac ventricle in the presence (IC50s = 175 and 1,660 nM, respectively) and absence of GTP (IC50s = 55.1 and 1,660 nM, respectively); inhibits acetylcholine-induced contractions in isolated guinea pig trachea (EC50 = 10.5 nM); inhibits histamine-induced airflow obstruction in a guinea pig model of ovalbumin-sensitized asthma at 10 μg/ml via inhalation

Formal name: rel-8-hydroxy-5-[(1R,2S)-1-hydroxy-2-[(1-methylethyl)amino]butyl]-2(1H)-quinolinone, monohydrochloride

Synonyms: 

Molecular weight: 326.8

CAS: 62929-91-3

Purity: ≥98%

Formulation: A crystalline solid

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