An internal standard for the quantification of probenecid by GC- or LC-MS

Probenecid-d14 – 1 mg

Brand:
Cayman
CAS:
1189657-87-1
Storage:
-20
UN-No:
Non-Hazardous - /

Probenecid-d14 is intended for use as an internal standard for the quantification of probenecid (Item No. 14981) by GC- or LC-MS. Probenecid is a benzoic acid derivative that inhibits organic anion transporters (OATs) but activates the transient receptor potential (TRP) channel TRPV2. It inhibits OAT1, OAT3, and OAT6 with Ki values of 6.3, 9.0, and 8.4 µM, respectively, as well as OAT2 with an IC50 value of 0.67 µM.{23928,23931,23929} It is a poor inhibitor of the organic cation transporters OCT1 and OCT2 (IC50 = 1.6 and 1.7 mM, respectively).{23932} It also acts as an agonist of TRPV2 (EC50 = 31.9 µM), eliciting nociceptive behavior under inflammatory conditions in mice. Formulations containing probenecid have been used in the treatment of gouty arthritis.{23933}  

 

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SKU: 26787 - 1 mg Category:

Description

An internal standard for the quantification of probenecid by GC- or LC-MS

Formal name: 4-[[di(propyl-1,1,2,2,3,3,3-d7)amino]sulfonyl]-benzoic acid

Synonyms: 

Molecular weight: 299.4

CAS: 1189657-87-1

Purity: ≥99% deuterated forms (d1-d14)

Formulation: A solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Ion Channel Modulation|Activators||Product Type|Biochemicals|Isotopically Labeled Standards|Deuterium||Product Type|Biochemicals|Transporter & Exchanger Modulators||Research Area|Immunology & Inflammation|Arthritis (Non-autoimmune)||Research Area|Neuroscience|Pain Research

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