A selective inhibitor of PRMT4/CARM1 (IC50 = 7.1 µM); reduces the prostate-specific antigen promoter activity in human prostate cancer LNCaP cells

PRMT4/CARM1 Inhibitor – 1 mg

Brand:
Cayman
CAS:
1020399-49-8
Storage:
-20
UN-No:
Non-Hazardous - /

PRMT4/CARM1 Inhibitor selectively blocks the activity of PRMT4/CARM1 with an IC50 value of 7.1 µM.{19872} It displays very low affinity towards PRMT1 and SET7 with IC50 values of 63 and 943 µM, respectively.{19872} In human prostate cancer LNCaP cells, this compound reduced the prostate-specific antigen promoter activity at 8-10 µM.{19872}  

 

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SKU: 11033 - 1 mg Category:

Description

A selective inhibitor of PRMT4/CARM1 (IC50 = 7.1 µM); reduces the prostate-specific antigen promoter activity in human prostate cancer LNCaP cells

Formal name: 3,5-bis[(3-bromo-4-hydroxyphenyl)methylene]-1-(phenylmethyl)-4-piperidinone

Synonyms:  Protein Arginine Methyltransferase 4/Coactivator-Associated Arginine Methyltransferase 1 Inhibitor

Molecular weight: 555.3

CAS: 1020399-49-8

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Methyltransferases||Research Area|Epigenetics, Transcription, & Translation|Writers|Histone Methylation

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