A cell-permeable benzylidene rhodamine that inhibits PRL-3 (IC50 = 900 nM for human PRL-3 in vitro)

PRL-3 Inhibitor – 1 mg

Brand:
Cayman
CAS:
893449-38-2
Storage:
-80
UN-No:
De Minimis - 3077 / 9

Phosphatase of regenerating liver 3 (PRL-3; also known as PTP4A3) plays critical roles in cell proliferation, motility, and invasion, and thus contributes to cancer metastasis. PRL-3 inhibitor is a cell-permeable benzylidene rhodamine that inhibits PRL-3 (IC50 = 900 nM for human PRL-3 in vitro), with minimal activity against other phosphatases.{30259,30260} It reduces the invasion of mouse melanoma B16F10 cells in a cell-based assay.{30259} PRL-3 inhibitor has been used to elucidate the actions of this enzyme, demonstrating that it dephosphorylates Tyr783 on integrin β1 and modulates VEGF-mediated endothelial cell migration.{30262,30264} It dose-dependently inhibits the growth and triggers apoptosis in cancer cell lines.{30261,30263}  

 

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Description

A cell-permeable benzylidene rhodamine that inhibits PRL-3 (IC50 = 900 nM for human PRL-3 in vitro), with minimal activity against other phosphatases; reduces the invasion of mouse melanoma B16F10 cells in a cell-based assay

Formal name: 5-[[5-bromo-2-[(2-bromophenyl)methoxy]phenyl]methylene]-2-thioxo-4-thiazolidinone

Synonyms:  BR-1|P0108|Phosphatase of Regenerating Liver 3 Inhibitor|PTP4A3 Inhibitor

Molecular weight: 485.2

CAS: 893449-38-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Phosphatases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Migration & Metastasis

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