A naturally occuring terpenoid that potently inhibits MAGL (IC50 = 93 nM); at 1 µM

Pristimerin – 5 mg

Brand:
Cayman
CAS:
1258-84-0
Storage:
-20
UN-No:
Non-Hazardous - /

Monoacylglycerol lipase (MAGL) hydrolyzes the endogenous cannabinoid 2-arachidonoyl glycerol (2-AG), terminating its capacity to activate cannabinoid receptors. Pristimerin is a naturally occurring terpenoid that potently inhibits MAGL (IC50 = 93 nM).{17593} Its actions are rapid, reversible, and noncompetitive.{17593} Pristimerin (1 µM) significantly increases 2-AG levels in isolated rat neurons, indicating that it inhibits endogenous MAGL in cultured cells.{17593} Moreover, it does not increase levels of palmitoyl ethanolamide, suggesting that pristimerin does not affect the activity of fatty acid amide hydrolase (FAAH).  

 

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Description

A naturally occuring terpenoid that potently inhibits MAGL (IC50 = 93 nM); at 1 µM, significantly inhibits endogenous MAGL in isolated rat neurons

Formal name: 3-hydroxy-9β,13α-dimethyl-2-oxo-24,25,26-trinoroleana-1(10),3,5,7-tetraen-29-oic acid, methyl ester

Synonyms:  Celastrol methyl ester|NSC 99281

Molecular weight: 464.6

CAS: 1258-84-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Natural Products|Terpenes||Product Type|Biochemicals|Small Molecule Inhibitors|Glycerolipid Lipases||Research Area|Neuroscience|Cannabinoid Research|Endocannabinoids

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