Mutations in the p53 tumor suppressor are found in many different neoplastic cells. PRIMA-1 restores sequence-specific DNA binding and transactivational activity to mutant p53 proteins at relatively high µM to mM concentrations.{9837} It is therefore a unique anti-oncogenic substance

PRIMA-1 – 50 mg

Brand:
Cayman
CAS:
5608-24-2
Storage:
-20
UN-No:
Non-Hazardous - /

Mutations in the p53 tumor suppressor are found in many different neoplastic cells. PRIMA-1 restores sequence-specific DNA binding and transactivational activity to mutant p53 proteins at relatively high µM to mM concentrations.{9837} It is therefore a unique anti-oncogenic substance, working as a re-activator of the apoptotic function of mutant p53 via conformational modulation of function-specific epitopes. PRIMA-1 represents a novel lead compound which may be further modified to provide more potent therapeutic agents acting via the reactivation mechanism.  

 

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SKU: 63520 - 50 mg Category:

Description

Mutations in the p53 tumor suppressor are found in many different neoplastic cells. PRIMA-1 restores sequence-specific DNA binding and transactivational activity to mutant p53 proteins at relatively high µM to mM concentrations.{9837} It is therefore a unique anti-oncogenic substance, working as a re-activator of the apoptotic function of mutant p53 via conformational modulation of function-specific epitopes. PRIMA-1 represents a novel lead compound which may be further modified to provide more potent therapeutic agents acting via the reactivation mechanism.

Formal name: 2,2-bis(hydroxymethyl)-3-quinuclidinone

Synonyms: 

Molecular weight: 185.2

CAS: 5608-24-2

Purity: ≥95%

Formulation: A crystalline solid

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