A catatoxic steroid that acts as an agonist of the rodent PXR at µM concentrations; mediates induction of hepatic CYP3A

Pregnenolone Carbonitrile – 250 mg

Brand:
Cayman
CAS:
1434-54-4
Storage:
-20
UN-No:
Non-Hazardous - /

Pregnenolone carbonitrile (PCN) is a catatoxic steroid that acts as an agonist of the rodent pregnane X receptor (PXR) at µM concentrations.{26748,26746,26747} It has been shown to mediate induction of hepatic cytochrome P450 3A, organic anion transporting peptide-2, and cholesterol 7α-hydroxylase, regulating both xenobiotic and bile acid homeostasis by enhancing hepatic uptake and biliary excretion.{26746,26747,26744} Activation of PXR by 50 mg/kg PCN administered to obesity-prone AKR/J mice has been reported to attenuate the development of high-fat diet-induced obesity and insulin resistance.{26745}  

 

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Description

A catatoxic steroid that acts as an agonist of the rodent PXR at µM concentrations; mediates induction of hepatic CYP3A, Oatp2, and Cyp7a1, regulating both xenobiotic and bile acid homeostasis

Formal name: 3β-hydroxy-20-oxo-pregn-5-ene-16α-carbonitrile

Synonyms:  PCN|Pregnenolone 16α-carbonitrile|SC-4674

Molecular weight: 341.5

CAS: 1434-54-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Diabetes||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Obesity||Research Area|Toxicology|Drug Metabolism|Cytochrome P450||Research Area|Toxicology|Drug Metabolism|Xenobiotic Sensing

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