A synthetic glucocorticoid with anti-inflammatory and immunosuppressant activities; inhibits paw swelling induced by sodium urate in mice by 86% at 12 mg/kg; reduces release of IL-6

Prednisone – 25 g

Brand:
Cayman
CAS:
53-03-2
Storage:
-20
UN-No:
Non-Hazardous - /

Prednisone is a synthetic glucocorticoid with anti-inflammatory and immunosuppressant activities.{19136} It inhibits paw swelling induced by sodium urate in mice by 86% when administered at a dose of 12 mg/kg.{42622} Prednisone reduces release of IL-6, monocyte chemoattractant protein-2 (MCP-2), MCP-3, RANTES, and TNF-α in stented arteries in a rabbit model of atherosclerosis.{42623} Formulations containing prednisone have been used in the treatment of non-Hodgkin lymphoma as part of CHOP chemotherapy and as anti-inflammatory or immunosuppressive agents.  

 

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Description

A synthetic glucocorticoid with anti-inflammatory and immunosuppressant activities; inhibits paw swelling induced by sodium urate in mice by 86% at 12 mg/kg; reduces release of IL-6, MCP-2, MCP-3, RANTES, and TNF-α in stented arteries in a rabbit model of atherosclerosis

Formal name: 17,21-dihydroxy-pregna-1,4-diene-3,11,20-trione

Synonyms:  1,2-Dehydrocortisone|NSC 10023

Molecular weight: 358.4

CAS: 53-03-2

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Lipids|Sterol Lipids||Research Area|Cancer||Research Area|Cardiovascular System|Cardiovascular Diseases|Atherosclerosis||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Glucocorticoids & Mineralocorticoids||Research Area|Immunology & Inflammation|Autoimmunity|Rheumatoid Arthritis||Research Area|Immunology & Inflammation|Immunosuppressants

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