A water-soluble ester of the poorly soluble parent molecule

Prednisolone Phosphate (sodium salt) – 5 g

Brand:
Cayman
CAS:
125-02-0
Storage:
-20
UN-No:
Non-Hazardous - /

Prednisolone is a synthetic analog of the natural glucocorticoid corticosterone that has anti-inflammatory and immunsuppressive actions.{19136,25867} It avidly binds both glucocorticoid and mineralocorticoid receptors (Kis = 2.4 and 37 nM).{25866} Prednisolone Phosphate, prepared as the sodium salt, is a water-soluble ester of the poorly soluble parent molecule, prednisolone.{25865} It is rapidly hydrolyzed in vivo to the parent molecule when administered intravenously.{25865} In addition, when given orally, prednisolone phosphate is more readily absorbed than prednisolone, resulting in a higher effective blood concentration of prednisolone.{25868}  

 

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Description

A water-soluble ester of the poorly soluble parent molecule, prednisolone; rapidly hydrolyzed in vivo to the parent molecule when administered intravenously; more readily absorbed than prednisolone when given orally

Formal name: 11β,17-dihydroxy-21-(phosphonooxy)-pregna-1,4-diene-3,20-dione, disodium salt

Synonyms:  Disodium Prednisolone 21-Phosphate

Molecular weight: 484.4

CAS: 125-02-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Glucocorticoids & Mineralocorticoids||Research Area|Immunology & Inflammation|Immunosuppressants

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