A chromene with anti-juvenile hormone activity; inhibits juvenile hormone biosynthesis in isolated spontaneously active cockroach corpora allata at ≥1 mM; inhibits development of the corpus allatum in newly eclosed female milkweed bugs and causes allatal regression when applied 120 hours post-eclosion in normally developing females at 8 μg/cm2 as a coating in Petri dish; induces precocious metamorphosis in milkweed bug second-stage nymphs when applied as a coating to Petri dishes at 0.4 and 0.7 μg/cm2; inhibits ovarian development in various insects

Precocene II – 50 mg

Brand:
Cayman
CAS:
644-06-4
Storage:
-20
UN-No:
Non-Hazardous - /

Precocene II is a chromene that has been found in A. houstonianum and has anti-juvenile hormone activity.{47615,47616,47617} It inhibits juvenile hormone biosynthesis in isolated spontaneously active cockroach (P. americana) corpora allata when used at concentrations of 1 mM or higher.{47615} Precocene II (8 μg/cm2 coating in Petri dish) inhibits development of the corpus allatum in newly eclosed female milkweed bugs and causes allatal regression when applied 120 hours post-eclosion in normally developing females.{47616} It induces precocious metamorphosis in milkweed bug second-stage nymphs when applied as a coating to Petri dishes at concentrations of 0.4 and 0.7 μg/cm2.{47617} Precocene II inhibits ovarian development in various insects, including milkweed bugs, cotton stainers, apple maggots, and Mexican bean beetles. Precocene II also inhibits production of the trichothecene mycotoxin 3-acetyldeoxy nivalenol (3-ADON; Item No. 11429) in F. graminearum (IC50 = 1.2 μM) without inhibiting fungal growth.{47618}  

 

Available on backorder

Add to quotes
SKU: 28480 - 50 mg Category:

Description

A chromene with anti-juvenile hormone activity; inhibits juvenile hormone biosynthesis in isolated spontaneously active cockroach corpora allata at ≥1 mM; inhibits development of the corpus allatum in newly eclosed female milkweed bugs and causes allatal regression when applied 120 hours post-eclosion in normally developing females at 8 μg/cm2 as a coating in Petri dish; induces precocious metamorphosis in milkweed bug second-stage nymphs when applied as a coating to Petri dishes at 0.4 and 0.7 μg/cm2; inhibits ovarian development in various insects, including milkweed bugs, cotton stainers, apple maggots, and Mexican bean beetles; inhibits production of the trichothecene mycotoxin 3-ADON in F. graminearum (IC50 = 1.2 μM) without inhibiting fungal growth

Formal name: 6,7-dimethoxy-2,2-dimethyl-2H-1-benzopyran

Synonyms:  Ageratochromene II|NSC 318792

Molecular weight: 220.3

CAS: 644-06-4

Purity: ≥98%

Formulation: A solid

Related products

  • CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}

    CAY10512 – 10 mg

    The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}  

     

    Brand:
    Cayman
    SKU:10009536 - 10 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • A powerful effector in both the TetR and revTetR transcriptional regulator systems

    Anhydrotetracycline (hydrochloride) – 50 mg

    The tetracycline repressor (TetR) is a transcriptional regulator which normally binds tightly to its palindromic tetO operator DNA, blocking gene expression.{17508} Tet causes the repressor to dissociate from the DNA, allowing transcription to occur. A novel reverse TetR (revTetR) requires tetracycline as a co-repressor to bind tetO and block transcription.{17509,17510} Anhydrotetracycline (hydrochloride) is a powerful effector in both the tetracycline repressor (TetR) and reverse TetR (revTetR) systems, binding the Tet repressor 35-fold more strongly than Tet.{17508,17511} Moreover, anhydrotetracycline poorly binds the 30S ribosomal subunit, compared to Tet,{17512} so it does not act as a general inhibitor of translation and is a poor antibiotic. Perhaps related to this, the concentration of anhydrotetracycline that inhibits eukaryotic cell growth is more than a 1,000-fold above the dose that alters transcription through TetR.{17508}  

     

    Brand:
    Cayman
    SKU:10009542 - 50 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}

    CAY10512 – 100 mg

    The nuclear factor-κB (NF-κB) regulates the expression of numerous genes involved in immunity and inflammation, cellular stress responses, growth, and apoptosis. Resveratrol, a polyphenolic trans-stilbene, is a known inhibitor of the activation of NF-κB and exhibits activity against a wide variety of cancer cells. CAY10512 is a substituted trans-stilbene analog of resveratrol that is 100-fold more potent as measured by antioxidant activity. The IC50 value for inhibition of TNFα-induced activation of NF-κB by CAY10512 is 0.15 µM compared to 20 µM by resveratrol.{14545}  

     

    Brand:
    Cayman
    SKU:10009536 - 100 mg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page
  • PtdIns-(3

    PtdIns-(3,4,5)-P3-biotin (sodium salt) – 100 µg

    The PtdIn phosphates play an important role in the generation and transduction of intracellular signals.{8344,4096,14518} PtdIns-(3,4,5)-P3-biotin is an affinity probe which allows the PIP3 to be detected through an interaction with the biotin ligand. This design allows PtdIns-(3,4,5)-P3-biotin to serve as a general probe for any protein with a high affinity binding interaction with inositol-(3,4,5)-triphosphate phospholipids, such as phosphatidylinositol 3-kinase, PTEN, or PH-domain-containing proteins.  

     

    Brand:
    Cayman
    SKU:10009531 - 100 µg

    Available on backorder

    Add to quotes
    Add to quotes
    View product page