An α1-AR antagonist; inhibits binding of the α1-AR ligand

Prazobind – 1 mg

Brand:
Cayman
CAS:
107021-36-3
Storage:
-20
UN-No:
Non-Hazardous - /

Prazobind is an α1-adrenergic receptor (AR) antagonist.{49225} It inhibits binding of the α1-AR ligand, BE-2254, in rat hippocampus and liver, which highly express α1A- and α1B-ARs, respectively (IC50 = 1 nM for both).{49226} It decreases norepinephrine-induced contraction of isolated guinea pig aorta when used at a concentration of 1 nM.{49227}  

 

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Description

An α1-AR antagonist; inhibits binding of the α1-AR ligand, BE-2254, in rat hippocampus and liver, which highly express α1A- and α1B-ARs, respectively (IC50 = 1 nM for both); decreases norepinephrine-induced contraction of isolated guinea pig aorta at 1 nM

Formal name: [4-(4-amino-6,7-dimethoxy-2-quinazolinyl)-1-piperazinyl]bicyclo[2.2.2]octa-2,5-dien-2-yl-methanone

Synonyms:  SZL-49

Molecular weight: 421.5

CAS: 107021-36-3

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Receptor Pharmacology||Research Area|Cardiovascular System|Vasculature|Vasodilation

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