A potent

Pravastatin (sodium salt) – 5 mg

Brand:
Cayman
CAS:
81131-70-6
Storage:
-20
UN-No:
Non-Hazardous - /

Hydroxymethylglutaryl-coenzyme A (HMG-CoA) reductase is the rate-limiting enzyme in the cholesterol biosynthetic pathway and the target of the “statin” class of cholesterol-lowering drugs.{15082} Pravastatin is a HMG-CoA reductase inhibitor that is a ring hydroxylated metabolite of mevastatin.{15312} It is a competitive inhibitor of HMG-CoA reductase with a Ki value of 2.3 nM for the active, open ring form of the molecule.{15312} Pravastatin, marketed as Pravachol™ or Lipostat™, is used to reduce LDL cholesterol and triglyceride levels and increase HDL cholesterol in the prevention of cardiovascular disease. In a study using dogs, five weeks of treatment with a dose 20 mg/kg per day reduced total plasma cholesterol levels by 29%.{15312}  

 

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SKU: 10010343 - 5 mg Category:

Description

A potent, competitive inhibitor of HMG-CoA reductase (Ki = 2.3 nM)

Formal name: 1S,2S,6S,7S,8R,8aR-hexahydro-βR,δR,6-trihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-1-naphthaleneheptanoic acid, monosodium salt

Synonyms: 

Molecular weight: 446.5

CAS: 81131-70-6

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Sterol Biosynthesis||Research Area|Cardiovascular System|Cardiovascular Diseases||Research Area|Cardiovascular System|Lipids & Lipoproteins|Cholesterol Metabolism||Research Area|Cardiovascular System|Lipids & Lipoproteins|Lipoproteins||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias

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