A potent HMG-CoA reductase inhibitor (Ki = 2.3 nM for the active

Pravastatin – 50 mg

Brand:
Cayman
CAS:
81093-37-0
Storage:
-20
UN-No:
Non-Hazardous - /

Pravastatin is a potent and competitive HMG-CoA reductase inhibitor (Ki = 2.3 nM for the active, open ring form of the molecule) that is a ring-hydroxylated metabolite of mevastatin (Item No. 10010340).{15312} In vivo, pravastatin reduces total plasma cholesterol levels by 29% in dogs when administered at a dose of 20 mg/kg per day for five weeks. Formulations containing pravastatin have been used to reduce LDL cholesterol and triglyceride levels and increase HDL cholesterol in the prevention of cardiovascular disease.  

 

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SKU: 10010342 - 50 mg Category:

Description

A potent HMG-CoA reductase inhibitor (Ki = 2.3 nM for the active, open ring form of the molecule); a ring hydroxylated metabolite of mevastatin; reduces total plasma cholesterol levels by 29% in dogs when administered at 20 mg/kg per day for five weeks

Formal name: (βR,δR,1S,2S,6S,8S,8aR)-1,2,6,7,8,8a-hexahydro-β,δ,6-trihydroxy-2-methyl-8-[(2S)-2-methyl-1-oxobutoxy]-1-naphthaleneheptanoic acid

Synonyms: 

Molecular weight: 424.5

CAS: 81093-37-0

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Sterol Biosynthesis||Research Area|Cardiovascular System|Cardiovascular Diseases||Research Area|Cardiovascular System|Lipids & Lipoproteins|Cholesterol Metabolism||Research Area|Cardiovascular System|Lipids & Lipoproteins|Lipoproteins||Research Area|Cell Biology|Cell Death|Ferroptosis||Research Area|Endocrinology & Metabolism|Metabolic Diseases|Dyslipidemias

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