A nonacidic

Pravadoline – 5 mg

Brand:
Cayman
CAS:
92623-83-1
Storage:
-20
UN-No:
Non-Hazardous - /

Pravadoline is a nonacidic, aminoalkylindole analgesic agent that inhibits cyclooxygenase.{13045} Like NSAIDs, pravadoline inhibits prostaglandin synthesis (IC50 = 5 μM in mouse brain microsomes) and displays antinociceptive activity (ED50 = 26 mg/kg in an acetylcholine-induced writhing assay in mice).{13045} In contrast to NSAIDs, pravadoline inhibits neuronally stimulated contractions in mouse vas deferens preparations (IC50 = 0.45 μM), an effect similar to that which is produced by opioid analgesics, yet is not attenuated by the opioid receptor antagonist, naloxone.{13045} Pravadoline does not produce gastrointestinal irritation following acute or chronic administration to rodents.{13045}  

 

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SKU: 10006973 - 5 mg Category:

Description

A nonacidic, aminoalkylindole analgesic agent that inhibits COX; inhibits PG synthesis (IC50 = 5 μM in mouse brain microsomes) and displays antinociceptive activity (ED50 = 26 mg/kg in an ACh-induced writhing assay in mice); inhibits neuronally stimulated contractions in mouse vas deferens preparations (IC50 = 0.45 μM)

Formal name: (4-methoxyphenyl)[2-methyl]-1-[2-(4-morpholinyl)ethyl]-1H-indol-3-yl]-methanone

Synonyms:  WIN 48,098

Molecular weight: 378.5

CAS: 92623-83-1

Purity: ≥98%

Formulation: A crystalline solid

Application|Mass Spectrometry||Product Type|Biochemicals|Analytical Standards||Product Type|Biochemicals|Drugs of Abuse||Research Area|Forensic Chemistry & Toxicology|Cannabinoids|Synthetic Cannabinoids

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