An amylin analog; stimulates cAMP production in HEK293 cells expressing human AMY1a

Pramlintide (acetate hydrate) – 10 mg

Brand:
Cayman
CAS:
196078-30-5
Storage:
-20
UN-No:
Non-Hazardous - /

Pramlintide is a non-amyloidogenic analog of the antidiabetic peptide hormone amylin (Item Nos. 24274 | 24275) that contains proline residues substituted at positions 25, 28, and 29.{46043} It stimulates cAMP production in HEK293 cells expressing human amylin receptor 1a (AMY1a), AMY2a, and AMY3a (EC50s = 0.35, 22.9, and 0.89 nM, respectively).{46044} Pramlintide inhibits human islet amyloid polypeptide fibrilization in a concentration-dependent manner.{46045} In vivo, pramlintide (200 pg/kg) reduces brain levels of amyloid-β (1-40) (Aβ40; Item No. 21617) and increases spontaneous alternation in the Y-maze in the Tg2576 transgenic mouse model of Alzheimer’s disease.{46046}  

 

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Description

An amylin analog; stimulates cAMP production in HEK293 cells expressing human AMY1a, AMY2a, and AMY3a (EC50s = 0.35, 22.9, and 0.89 nM, respectively); inhibits human islet amyloid polypeptide fibrilization in a concentration-dependent manner; reduces brain levels of Aβ40 and increases spontaneous alternation in the Y-maze in the Tg2576 transgenic mouse model of Alzheimer’s disease at 200 pg/kg,

Formal name: 25-L-proline-28-L-proline-29-L-proline-amylin (human), monoacetate hydrate

Synonyms: 

Molecular weight: 3,949.40

CAS: 196078-30-5

Purity: ≥95%

Formulation: A solid

Product Type|Biochemicals|Peptides||Product Type|Biochemicals|Receptor Pharmacology|Agonists||Research Area|Endocrinology & Metabolism|Hormones & Receptors||Research Area|Neuroscience|Neurodegenerative Disorders|Alzheimer’s Disease

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