A general inhibitor of DUBs

PR-619 – 5 mg

Brand:
Cayman
CAS:
2645-32-1
Storage:
-20
UN-No:
Non-Hazardous - /

PR-619 is a general inhibitor of deubiquitylating enzymes (DUBs), significantly reducing the activity of a panel of DUBs with EC50 values ranging from 5-20 µM.{27951} It is cell-permeable and reversible in its action.{27951} It is selective for DUBs over other proteases.{27951} PR-619 induces the accumulation of polyubiquitinated proteins in cells, including those not involved in the ubiquitin-proteasome system.{27954} It is used to study the role of DUBs in diverse pathways, including protein turnover and neurodegeneration.{27952,27953,27955}  

 

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Description

A general inhibitor of DUBs, significantly reducing the activity of a panel of DUBs with EC50 values ranging from 5-20 µM; cell-permeable and reversible in its action

Formal name: C,​C’-​(2,​6-​diamino-​3,​5-​pyridinediyl) ester thiocyanic acid

Synonyms:  2,6-Diamino-3,5-dithiocyanopyridine|DUB Inhibitor V

Molecular weight: 223.3

CAS: 2645-32-1

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|Ubiquitin Ligase System||Research Area|Cell Biology|Proteolysis|Ubiquitin/Proteasome System

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