An inhibitor of IGF-1R; inhibits autophosphorylation of the recombinant IGF-1R kinase domain (IC50 = 50 = 12 μM); reduces cell viability of U87MG glioma cells (IC50 = 5 μM) and induces apoptosis and inhibits cell migration in a concentration-dependent manner; inhibits IGF-1-stimulated proliferation of MCF-7 cells in vitro (IC50 = 6 μM) and reduces tumor growth in an MCNeuA model of murine breast cancer at 50 and 100 mg/kg; has antimalarial activity against P. falciparum strain 3D7 (EC50 = 53 nM)

PQ401 – 50 mg

Brand:
Cayman
CAS:
196868-63-0
Storage:
-20
UN-No:
Non-Hazardous - /

PQ401 is an inhibitor of insulin-like growth factor 1 receptor (IGF-1R).{42758} It inhibits autophosphorylation of the recombinant IGF-1R kinase domain (IC50 = 50 = 12 μM). PQ401 reduces cell viability of U87MG glioma cells with an IC50 value of 5 μM and induces apoptosis and inhibits cell migration in a concentration-dependent manner.{42759} It inhibits IGF-1-stimulated proliferation of MCF-7 cells in vitro (IC50 = 6 μM) and reduces tumor growth in an MCNeuA model of murine breast cancer when administered at doses of 50 and 100 mg/kg.{42758} PQ401 also has antimalarial activity against the P. falciparum strain 3D7 (EC50 = 53 nM).{42760}  

 

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Description

An inhibitor of IGF-1R; inhibits autophosphorylation of the recombinant IGF-1R kinase domain (IC50 = 50 = 12 μM); reduces cell viability of U87MG glioma cells (IC50 = 5 μM) and induces apoptosis and inhibits cell migration in a concentration-dependent manner; inhibits IGF-1-stimulated proliferation of MCF-7 cells in vitro (IC50 = 6 μM) and reduces tumor growth in an MCNeuA model of murine breast cancer at 50 and 100 mg/kg; has antimalarial activity against P. falciparum strain 3D7 (EC50 = 53 nM)

Formal name: N-(5-chloro-2-methoxyphenyl)-N’-(2-methyl-4-quinolinyl)-urea

Synonyms: 

Molecular weight: 341.8

CAS: 196868-63-0

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Antiparasitics|Antiprotozoals||Product Type|Biochemicals|Kinase Inhibitors|IGF-1R/InsR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Cell Death|Apoptosis||Research Area|Cancer|Cell Migration & Metastasis||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling||Research Area|Cell Biology|Cell Signaling|Growth Factor Receptors||Research Area|Immunology & Inflammation||Research Area|Infectious Disease|Parasitic Diseases|Malaria

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