Arachidonic acid is converted by microsomal CYP450 enzymes to a variety of epoxides

PPOH – 50 mg

Brand:
Cayman
CAS:
206052-01-9
Storage:
-20
UN-No:
Non-Hazardous - /

Arachidonic acid is converted by microsomal CYP450 enzymes to a variety of epoxides, ω-1 and ω-hydroxylated compounds via what is known as the epoxidase pathway.{313,403,823} PPOH is a selective inhibitor of the epoxygenation reactions catalyzed by specific CYP450 isozymes.{8589} PPOH inhibits the formation of arachidonate 11,12 epoxides by CYP4A2 and CYP4A3 enzymes with an IC50 of 9 µM, but has effect on the formation of 20-HETE, the ω-hydroxylation product of CYP4A1.{8588}  

 

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Description

Arachidonic acid is converted by microsomal CYP450 enzymes to a variety of epoxides, ω-1 and ω-hydroxylated compounds via what is known as the epoxidase pathway.{313,403,823} PPOH is a selective inhibitor of the epoxygenation reactions catalyzed by specific CYP450 isozymes.{8589} PPOH inhibits the formation of arachidonate 11,12 epoxides by CYP4A2 and CYP4A3 enzymes with an IC50 value of 9 µM, but has effect on the formation of 20-HETE, the ω-hydroxylation product of CYP4A1.{8588}

Formal name: 2-(2-propynyloxy)-benzenehexanoic acid

Synonyms: 

Molecular weight: 246.3

CAS: 206052-01-9

Purity: ≥99%

Formulation: A crystalline solid

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