An inhibitor NF-κB activation in vitro and in vivo (IC50 = 5 µM)

PPM-18 – 25 mg

Brand:
Cayman
CAS:
65240-86-0
Storage:
-20
UN-No:
Non-Hazardous - /

PPM-18 is a naphthoquinone compound that inhibits NF-κB activation in vitro and in vivo (IC50 = 5 µM).{8949,18439} Through this action, it inhibits the expression of inducible nitric oxide synthase (iNOS) in macrophages treated with lipopolysaccharide and suppresses inflammation and sepsis.{8949}  

 

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Description

An inhibitor NF-κB activation in vitro and in vivo (IC50 = 5 µM)

Formal name: N-(1,4-dihydro-1,4-dioxo-2-naphthalenyl)-benzamide

Synonyms:  NSC 73233

Molecular weight: 277.3

CAS: 65240-86-0

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|TNF-α/NF-κB Signaling||Research Area|Cell Biology|Cell Signaling|NF-κB Signaling||Research Area|Epigenetics, Transcription, & Translation|Transcription Factors||Research Area|Immunology & Inflammation|Innate Immunity|Pattern Recognition||Research Area|Immunology & Inflammation|Innate Immunity|Sepsis/Shock||Research Area|Immunology & Inflammation|Innate Immunity|STING||Research Area|Infectious Disease

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