An irreversible inhibitor of glandular and plasma kallikreins that has been shown to prevent apolipoprotein proteolysis in dextran sulfate-precipitated human plasma LDL and to inhibit serum atrial natriuretic peptide cleavage

PPACKII (trifluoroacetate salt) – 1 mg

Brand:
Cayman
CAS:
649748-23-2
Storage:
-20
UN-No:
Non-Hazardous - /

Kallikreins are a class of serine proteases that affect the release of vasodepressor peptides or kinins from a plasma substrate. PPACKII is a specific and irreversible inhibitor of glandular and plasma kallikreins.{24966} At micromolar concentrations it has been shown to prevent apolipoprotein proteolysis in dextran sulfate-precipitated human plasma LDL and to inhibit serum atrial natriuretic peptide cleavage.{2805} PPACKII has also been reported to inactivate the amidolytic activity of native human Hageman Factor (Factor XII) at 5.3 μM.{24967}  

 

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Description

An irreversible inhibitor of glandular and plasma kallikreins that has been shown to prevent apolipoprotein proteolysis in dextran sulfate-precipitated human plasma LDL and to inhibit serum atrial natriuretic peptide cleavage

Formal name: D-phenylalanyl-N-[(1S)-4-[(aminoiminomethyl)amino]-1-(chloroacetyl)butyl]-L-phenylalaninamide, bis(trifluoroacetate)

Synonyms:  H-D-Phe-Phe-Arg-Chloromethyl Ketone

Molecular weight: 729.1

CAS: 649748-23-2

Purity: ≥95%

Formulation: A crystalline solid

Product Type|Biochemicals|Small Molecule Inhibitors|MMPs||Product Type|Biochemicals|Small Molecule Inhibitors|Peptidases & Proteases||Research Area|Cardiovascular System|Blood|Thrombosis||Research Area|Cardiovascular System|Lipids & Lipoproteins|Lipoproteins

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