Description
A potent dual inhibitor of tyrosine and phosphoinositide kinases (IC50s = 2-60 nM for p110α, mTOR, Src, Abl, and VEGFR); demonstrates >90% inhibition of tyrosine kinases and 50 = 50 nM) in vitro; blocks VEGF-driven HUVEC tube formation (IC50 = 0.31 nM); inhibits MEKK2/MAP3K2 (IC50 = 31 nM),
Formal name: 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Synonyms:
Molecular weight: 319.4
CAS: 1092788-83-4
Purity: ≥98%
Formulation: A crystalline solid
Product Type|Biochemicals|Kinase Inhibitors|Abl Family & Bcr-Abl||Product Type|Biochemicals|Kinase Inhibitors|mTOR||Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Kinase Inhibitors|PI3K||Product Type|Biochemicals|Kinase Inhibitors|SRC Family||Product Type|Biochemicals|Kinase Inhibitors|VEGFR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Angiogenesis||Research Area|Cancer|Cell Signaling|Abl family & Bcr-Abl Signaling||Research Area|Cancer|Cell Signaling|ERK/MAPK Signaling||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Cancer|Cell Signaling|SRC Family Signaling
