A potent dual inhibitor of tyrosine and phosphoinositide kinases (IC50s = 2-60 nM for p110α

PP121 – 25 mg

Brand:
Cayman
CAS:
1092788-83-4
Storage:
-20
UN-No:
Non-Hazardous - /

PP121 is a potent dual inhibitor of tyrosine and phosphoinositide kinases with IC50 values ranging from 2 to 60 nM for p110α, mTOR, Src, Abl, and VEGFR.{17883} It demonstrates >90% inhibition of tyrosine kinases and 50 = 50 nM) in vitro. It blocks VEGF-driven human umbilical vein endothelial cell (HUVEC) tube formation (IC50 = 0.31 nM), an in vitro model of tumor angiogenesis. PP121 also inhibits MEKK2/MAP3K2 (IC50 = 31 nM), a kinase important for tumor growth and metastasis.{38183}  

 

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Description

A potent dual inhibitor of tyrosine and phosphoinositide kinases (IC50s = 2-60 nM for p110α, mTOR, Src, Abl, and VEGFR); demonstrates >90% inhibition of tyrosine kinases and 50 = 50 nM) in vitro; blocks VEGF-driven HUVEC tube formation (IC50 = 0.31 nM); inhibits MEKK2/MAP3K2 (IC50 = 31 nM),

Formal name: 1-cyclopentyl-3-(1H-pyrrolo[2,3-b]pyridin-5-yl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Synonyms: 

Molecular weight: 319.4

CAS: 1092788-83-4

Purity: ≥98%

Formulation: A crystalline solid

Product Type|Biochemicals|Kinase Inhibitors|Abl Family & Bcr-Abl||Product Type|Biochemicals|Kinase Inhibitors|mTOR||Product Type|Biochemicals|Kinase Inhibitors|Other Serine/Threonine Kinases||Product Type|Biochemicals|Kinase Inhibitors|PI3K||Product Type|Biochemicals|Kinase Inhibitors|SRC Family||Product Type|Biochemicals|Kinase Inhibitors|VEGFR Family||Product Type|Biochemicals|Small Molecule Inhibitors|Kinases||Research Area|Cancer|Angiogenesis||Research Area|Cancer|Cell Signaling|Abl family & Bcr-Abl Signaling||Research Area|Cancer|Cell Signaling|ERK/MAPK Signaling||Research Area|Cancer|Cell Signaling|Growth Factor Receptor Signaling||Research Area|Cancer|Cell Signaling|PI3K/Akt/mTOR Signaling||Research Area|Cancer|Cell Signaling|SRC Family Signaling

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