An organochlorine pesticide; induces 94.2% mortality of malaria mosquito (A. quadrimaculatus) fourth-instar larvae and 100% mortality of A. aegypti larvae at 0.01 and 0.05 ppm

p,p’-DDT – 10 mg

Brand:
Cayman
CAS:
50-29-3
Storage:
-20
UN-No:
De Minimis - 2811 / 6.1

p,p’-DDT is an organochlorine pesticide that induces 94.2% mortality of malaria mosquito (A. quadrimaculatus) fourth-instar larvae and 100% mortality of A. aegypti larvae when used at concentrations of 0.01 and 0.05 ppm, respectively.{37594,37593} It increases secretion of estradiol by granulosa and theca cell co-cultures isolated from porcine ovarian follicles when used at concentrations of greater than or equal to 4 ng/ml and increases apoptosis in isolated human peripheral blood mononuclear cells (PBMCs) when used at concentrations ranging from 80 to 150 µg/ml.{36699,39802} p,p’-DDT (5 nmol/kg, i.p.) increases tumor growth in a DLD1 colorectal adenocarcinoma nude mouse xenograft model.{43286} It induces 100% mortality of C. auratus (goldfish) at 0.25 ppm and is lethal to rats but not hamsters (LD50s = 120 and ~5,000 mg/kg, respectively).{36700,37594} p,p’-DDT is a persistent organic pollutant (POP) and is elevated in the sera of pregnant women in malaria-endemic regions of South Africa.{37597} Formulations containing p,p’-DDT have been used to control insect populations, including mosquitos, in agriculture and to prevent the spread of malaria and typhus.  

 

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SKU: 24243 - 10 mg Category:

Description

An organochlorine pesticide; induces 94.2% mortality of malaria mosquito (A. quadrimaculatus) fourth-instar larvae and 100% mortality of A. aegypti larvae at 0.01 and 0.05 ppm, respectively; increases secretion of estradiol by granulosa and theca cell co-cultures isolated from porcine ovarian follicles at ≥4 ng/ml; increases apoptosis in isolated human PBMCs from 80-150 µg/ml; increases tumor growth in a DLD1 colorectal adenocarcinoma nude mouse xenograft model at 5 nmol/kg; induces 100% mortality of C. auratus (goldfish) at 0.25 ppm; lethal to rats but not hamsters (LD50s = 120 and ~5,000 mg/kg, respectively); is a POP and is elevated in the sera of pregnant women in malaria-endemic regions of South Africa

Formal name: 1,1′-(2,2,2-trichloroethylidene)bis[4-chloro-benzene]

Synonyms:  p,p’-Dichlorodiphenyltrichloroethane|4,4′-DDT|4,4′-Dichlorodiphenyltrichloroethane|Dicophaner|NSC 8939

Molecular weight: 354.5

CAS: 50-29-3

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Pesticides|Insecticides||Research Area|Cancer||Research Area|Cell Biology|Cell Death|Apoptosis||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Estrogens & Progestins||Research Area|Endocrinology & Metabolism|Reproductive Biology||Research Area|Toxicology|Cell Health & Viability||Research Area|Toxicology|Environmental|Agriculture||Research Area|Toxicology|Environmental|Aquatic Systems||Research Area|Toxicology|Environmental|Steroids

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