A metabolite and degradation product of the pesticide DDT; accumulates in various fish and sediment surrounding a DDT manufacturing plant; inhibits estrogen binding to rtERs (IC50 = 8 µM); induces concentration-dependent secretion of estradiol by granulosa and theca cell co-cultures isolated from porcine ovarian follicles; induces concentration-dependent secretion of estradiol by granulosa and theca cell co-cultures isolated from porcine ovarian follicles; decreases ATP levels

p,p’-DDE – 100 mg

Brand:
Cayman
CAS:
72-55-9
Storage:
-20
UN-No:
De Minimis - 3077 / 9

p,p’-DDE is a metabolite and degradation product of the organochlorine pesticide DDT.{39801} It accumulates in smallmouth buffalo, channel catfish, and largemouth bass as well as sediment in the Huntsville Spring Branch-Indian Creek tributary system surrounding a DDT manufacturing plant where it is considered a persistent organic pollutant (POP). p,p’-DDE inhibits estrogen binding to rainbow trout estrogen receptors (rtERs) with an IC50 value of 8 µM.{12991} It induces concentration-dependent secretion of estradiol by granulosa and theca cell co-cultures isolated from porcine ovarian follicles.{39802} p,p’-DDE (50-100 µM) also decreases ATP levels, the proportion of sperm with high mitochondrial membrane potential, and motility of human sperm in vitro.{42280}  

 

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SKU: 24241 - 100 mg Category:

Description

A metabolite and degradation product of the pesticide DDT; accumulates in various fish and sediment surrounding a DDT manufacturing plant; inhibits estrogen binding to rtERs (IC50 = 8 µM); induces concentration-dependent secretion of estradiol by granulosa and theca cell co-cultures isolated from porcine ovarian follicles; induces concentration-dependent secretion of estradiol by granulosa and theca cell co-cultures isolated from porcine ovarian follicles; decreases ATP levels, the proportion of sperm with high mitochondrial membrane potential, and motility of human sperm in vitro from 50-100 µM,

Formal name: 1,1′-(2,2-dichloroethenylidene)bis[4-chloro-benzene]

Synonyms:  p,p’-Dichlorodiphenyldichloroethylene|4,4′-DDE|4,4′-Dichlorodiphenyldichloroethylene|NSC 1153

Molecular weight: 318

CAS: 72-55-9

Purity: ≥98%

Formulation: A solid

Product Type|Biochemicals|Pesticides||Product Type|Biochemicals|Receptor Pharmacology||Product Type|Biochemicals|Xenobiotic Metabolites||Research Area|Endocrinology & Metabolism|Hormones & Receptors|Estrogens & Progestins||Research Area|Endocrinology & Metabolism|Reproductive Biology||Research Area|Toxicology|Cell Health & Viability|Mitochondrial (dys)Function||Research Area|Toxicology|Drug Metabolism||Research Area|Toxicology|Environmental|Endocrine Disruption||Research Area|Toxicology|Environmental|Steroids

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